##fileformat=VCFv4.3
##source=MutationSieve-0.1.0.dev1
##reference=synthetic-MutationSieve-v1
##MutationSieveQUALPolicy=missing_until_exact_deployment_calibration
##MutationSieveScoreInterpretation=transparent_rank_not_probability
##MutationSieveAutomaticReporting=disabled
##contig=<ID=chrSynthetic,length=12000>
##FILTER=<ID=REVIEW,Description="Research hypothesis requiring human review; not reportable">
##FILTER=<ID=LOWCONF,Description="Candidate retained in audit but not in this review VCF">
##INFO=<ID=TYPE,Number=1,Type=String,Description="Normalized small-variant class">
##INFO=<ID=TIER,Number=1,Type=String,Description="MutationSieve research tier">
##INFO=<ID=STATE,Number=1,Type=String,Description="Explicit candidate decision or no-call state">
##INFO=<ID=TARGET,Number=1,Type=String,Description="Target identifier">
##INFO=<ID=GENE,Number=1,Type=String,Description="Target gene annotation">
##INFO=<ID=MSCORE,Number=1,Type=Float,Description="Transparent evidence rank; not a calibrated probability">
##INFO=<ID=PVALUE,Number=1,Type=Float,Description="Error-model tail probability after local sequence-family Bonferroni adjustment">
##INFO=<ID=QVALUE,Number=1,Type=Float,Description="Full callable-search multiplicity-adjusted value">
##INFO=<ID=NTEST,Number=1,Type=Integer,Description="Declared number of searched hypotheses">
##INFO=<ID=PON,Number=1,Type=String,Description="Panel-of-normals compatibility state">
##INFO=<ID=PONREC,Number=1,Type=Integer,Description="Normals with alternate evidence at this allele">
##INFO=<ID=UNIT,Number=1,Type=String,Description="Primary support and depth counting unit">
##INFO=<ID=RAWALT,Number=1,Type=Integer,Description="Raw alternate alignment records used for discovery">
##INFO=<ID=RAWDP,Number=1,Type=Integer,Description="Raw high-quality anchor record depth">
##INFO=<ID=CFALT,Number=1,Type=Integer,Description="Alternate BAM-coordinate families; audit proxy, not molecules">
##INFO=<ID=CFDP,Number=1,Type=Integer,Description="Informative BAM-coordinate families; audit proxy, not molecules">
##INFO=<ID=UMIALT,Number=1,Type=Integer,Description="Alternate explicit UMI consensus families">
##INFO=<ID=UMIDP,Number=1,Type=Integer,Description="Informative explicit UMI consensus families">
##INFO=<ID=HAPALT,Number=1,Type=Integer,Description="Alternate primary-unit observations favored by local haplotype rescore">
##INFO=<ID=HP,Number=1,Type=Integer,Description="Local homopolymer run length">
##FORMAT=<ID=GT,Number=1,Type=String,Description="Candidate genotype; missing until reportability validation">
##FORMAT=<ID=DP,Number=1,Type=Integer,Description="Depth in the declared primary counting unit">
##FORMAT=<ID=AD,Number=R,Type=Integer,Description="Reference and alternate support in the primary counting unit">
##FORMAT=<ID=AF,Number=A,Type=Float,Description="Alternate support fraction in the primary counting unit">
##FORMAT=<ID=ADF,Number=R,Type=Integer,Description="Forward reference and alternate declared primary-unit observations">
##FORMAT=<ID=ADR,Number=R,Type=Integer,Description="Reverse reference and alternate declared primary-unit observations">
#CHROM	POS	ID	REF	ALT	QUAL	FILTER	INFO	FORMAT	DEVELOPMENT_POSITIVE
chrSynthetic	1201	mutationsieve_1	T	A	.	REVIEW	TYPE=SNV;TIER=REVIEW;STATE=REVIEW_CANDIDATE;TARGET=TARGET_A;GENE=GENE_A;MSCORE=0.638379;PVALUE=1;QVALUE=1;NTEST=20896000;PON=compatible_empirical;PONREC=0;UNIT=paired_fragment;RAWALT=14;RAWDP=55;CFALT=13;CFDP=50;UMIALT=0;UMIDP=0;HAPALT=13;HP=1	GT:DP:AD:AF:ADF:ADR	./.:50:37,13:0.26:15,9:22,4
chrSynthetic	2201	mutationsieve_2	C	A	.	REVIEW	TYPE=SNV;TIER=REVIEW;STATE=REVIEW_CANDIDATE;TARGET=TARGET_A;GENE=GENE_A;MSCORE=0.193945;PVALUE=1;QVALUE=1;NTEST=20896000;PON=compatible_empirical;PONREC=0;UNIT=paired_fragment;RAWALT=3;RAWDP=38;CFALT=3;CFDP=36;UMIALT=0;UMIDP=0;HAPALT=3;HP=1	GT:DP:AD:AF:ADF:ADR	./.:36:33,3:0.0833333:20,2:13,1
chrSynthetic	4480	mutationsieve_3	C	CAA	.	REVIEW	TYPE=INS;TIER=REVIEW;STATE=REVIEW_CANDIDATE;TARGET=HOMOPOLYMER_TARGET;GENE=GENE_H;MSCORE=0.341863;PVALUE=1;QVALUE=1;NTEST=20896000;PON=compatible_empirical;PONREC=0;UNIT=paired_fragment;RAWALT=16;RAWDP=67;CFALT=14;CFDP=14;UMIALT=0;UMIDP=0;HAPALT=9;HP=40	GT:DP:AD:AF:ADF:ADR	./.:58:0,14:0.241379:0,10:0,4
chrSynthetic	5299	mutationsieve_4	CAGA	C	.	REVIEW	TYPE=DEL;TIER=REVIEW;STATE=REVIEW_CANDIDATE;TARGET=HOMOPOLYMER_TARGET;GENE=GENE_H;MSCORE=0.60758;PVALUE=1;QVALUE=1;NTEST=20896000;PON=compatible_empirical;PONREC=0;UNIT=paired_fragment;RAWALT=11;RAWDP=62;CFALT=11;CFDP=54;UMIALT=0;UMIDP=0;HAPALT=11;HP=2	GT:DP:AD:AF:ADF:ADR	./.:54:43,11:0.203704:20,2:23,9
